Status of the Quality System Team – June 27, 2025
The following site may be useful to draw to people’s attention when specifying objectives on the Etaluma: https://www.microscope.healthcare.nikon.com/microtools/resolution-calculator/#Focus I have configured a custom resolution calculation using the sensor data supplied by Etaluma, here exemplified at 10x/0.3NA: To take account of the shorter tube lens (which gives ¼ magnification expected cf Nikon 200mm tube) I have…
Work in progress … **************** T cell–Engaging Immunotherapies Pose a Predictable but Complex RiskT cell–engaging bispecific antibodies (BsAbs), particularly those targeting CD3 and a tumor-associated antigen, have emerged as a powerful class of immunotherapies. These agents leverage endogenous T cells to induce targeted tumor cell death, often achieving deep and durable responses in hematologic malignancies….
Image analysis for force from videos of deflected PDMS beams In the summer, Yimei Du from University of Rochester visited Truskey lab to help with the μSiM Vasc-SkM system. Besides working with the chip culture, she helped improve the image analysis of the videos of PDMS beam deflection for more accurate myobundle force analysis. We…
The 2025 Rochester MPS Day Summary provides an overview of the event, highlighting registration details, participant feedback, and suggestions for future improvements. The event had a total of 130 registrations, with 88 in-person and 26 virtual attendees. Participants represented various organizations, including the University of Rochester, RIT, Duke, NIH/NCATS, and several industry partners. Feedback indicated that…
Introduction During the January TraCe-bMPS progress meeting, Jon Flax presented some interesting findings in the iPSC-derived extended endothelial culture method brain microvascular endothelial cell-like cells (EECM-BMECs, hereafter referred to as BMECs) [1]. While these BMECs tended to have high expression of most transmembrane transport proteins, they had relatively low expression of p-glycoprotein (ABCB1/MDR1) (Figure 1)….
Since the last TraCe-bMPS update in April, we continued to explore different conditions to optimize the μSiM hVasc-SkM systems to obtain stable results. Enhanced imaging for PDMS beams with Rhodamine staining Previously we established a MATLAB program that detects the border of the PDMS beams and converts the movement of the PDMS beam from myobundle…