Quality System and LOI Updates (August ’25)
LoI and QS Slides for NIH monthly mtg 28 Aug 2025
Letters of Intent Draft sent to C-Path on August 15
LoI and QS Slides for NIH monthly mtg 28 Aug 2025
Letters of Intent Draft sent to C-Path on August 15
Introduction Our goal was to develop a COMSOL model for the bottom channel of the µSiM that can be accessed and easily used by anyone with a COMSOL license. Previously developed simulations for the µSiM rely on the CAD import module, which can introduce unnecessary complications with regards to accessibility and ease-of-use, particularly to expand…
Image analysis for force from videos of deflected PDMS beams In the summer, Yimei Du from University of Rochester visited Truskey lab to help with the μSiM Vasc-SkM system. Besides working with the chip culture, she helped improve the image analysis of the videos of PDMS beam deflection for more accurate myobundle force analysis. We…
The following site may be useful to draw to people’s attention when specifying objectives on the Etaluma: https://www.microscope.healthcare.nikon.com/microtools/resolution-calculator/#Focus I have configured a custom resolution calculation using the sensor data supplied by Etaluma, here exemplified at 10x/0.3NA: To take account of the shorter tube lens (which gives ¼ magnification expected cf Nikon 200mm tube) I have…
Introduction During the January TraCe-bMPS progress meeting, Jon Flax presented some interesting findings in the iPSC-derived extended endothelial culture method brain microvascular endothelial cell-like cells (EECM-BMECs, hereafter referred to as BMECs) [1]. While these BMECs tended to have high expression of most transmembrane transport proteins, they had relatively low expression of p-glycoprotein (ABCB1/MDR1) (Figure 1)….
Work in progress … **************** T cell–Engaging Immunotherapies Pose a Predictable but Complex RiskT cell–engaging bispecific antibodies (BsAbs), particularly those targeting CD3 and a tumor-associated antigen, have emerged as a powerful class of immunotherapies. These agents leverage endogenous T cells to induce targeted tumor cell death, often achieving deep and durable responses in hematologic malignancies….
The 2025 Rochester MPS Day Summary provides an overview of the event, highlighting registration details, participant feedback, and suggestions for future improvements. The event had a total of 130 registrations, with 88 in-person and 26 virtual attendees. Participants represented various organizations, including the University of Rochester, RIT, Duke, NIH/NCATS, and several industry partners. Feedback indicated that…