Quality System and LOI Updates (August ’25)

Administrative: Molly Van Wyk is no longer TraCe-bMPS admin. Assumed Bonnie’s job as Sr. Admin in BME. Will continue to help until position is replaced. Quality Systems meetings are moving to Wednesdays only: 9:30 -10:00 AM Progress meetings will be on Tuesdays 9:00 – 10:00 AM starting in Spring. One more 4 PM meeting planned…

CRE_Bispecific_Antibody_CRS_and_ICANS_Neurotoxicity_Guidance_Feb2024 51899285fnl_Immunotoxic Potential of PharmaceuticalsWe are considering Bispecific T cell engagers (BiTEs) [1] as an alternative to a CAR T driven cytokine release as an immunotherapy focused DDT. BiTEs are monoclonal antibodies engineered to have one arm that recognizes a T Cell surface antigen and another that recognizes a tumor antigen. There are number of…

The μSiM Vasc-SkM Microphysiological development can be separated into 4 parts: Media tuning for integrated culture Force sensing element setup Assembly of the μSiM Vasc-SkM and setting up the perfusion Transendothelial Electrical Resistance (TEER) measurement of the Vast component Work has been done on the first 2 parts. Media tuning for integrated culture In order…

Since the last TraCe-bMPS update in April, we continued to explore different conditions to optimize the μSiM hVasc-SkM systems to obtain stable results.  Enhanced imaging for PDMS beams with Rhodamine staining  Previously we established a MATLAB program that detects the border of the PDMS beams and converts the movement of the PDMS beam from myobundle…