Quality System and LOI Updates (August ’25)
LoI and QS Slides for NIH monthly mtg 28 Aug 2025
Letters of Intent Draft sent to C-Path on August 15
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IMR90 EECM-BMEC-Like Cells Lack P-gp Efflux Activity
Introduction During the January TraCe-bMPS progress meeting, Jon Flax presented some interesting findings in the iPSC-derived extended endothelial culture method brain microvascular endothelial cell-like cells (EECM-BMECs, hereafter referred to as BMECs) [1]. While these BMECs tended to have high expression of most transmembrane transport proteins, they had relatively low expression of p-glycoprotein (ABCB1/MDR1) (Figure 1)….
