Utilizing the μSIM to model brain endothelial barrier changes in Cerebral Amyloid Angiopathy
Introduction Vascular hyperpermeability and hemorrhagic stroke are hallmark symptoms of Cerebral Amyloid Angiopathy (CAA), a cerebrovascular disease characterized by amyloid-β deposition around the brain microvasculature. In CAA pathogenesis, vascular Aβ accumulation contributes to structural alterations and loss of integrity in the neurovascular unit/blood-brain barrier (NVU/BBB) resulting in “leakier” blood vessels, intracerebral hemorrhages, increased risk of…