R61: 12 Month Progress to NIH Slide Decks

Introduction In a previous post, an initial version of the flow module and its sealing components were described. In order to improve the initial version based on collaborators’ feedback, several modifications have been made to simplify the device assembly for the end-user (Fig. 1) and address concerns about: 1) Local regions of high shear stress…

Introduction The ApoE4 allele of the apolipoprotein E (ApoE) gene is the greatest known genetic risk factor for Alzheimer’s disease. Further it has been linked to increased susceptibility and duration of infection. On the other hand, the ApoE3 allele has been shown to have a protective effect against severe sepsis. Importantly, ApoE has an important role…

Introduction Breakdown of the blood-brain barrier (BBB) is one of the earliest signs of sepsis and is linked with long-term cognitive impairment. As animal models poorly recapitulate human sepsis, alternative approaches are direly needed to understand sepsis-associated brain injury and develop strategies that protect against cognitive decline. To fill this gap, we are developing a…