Solid State Nanopores in Biosensing
Multi-Nanopore Force Spectroscopy for DNA Analysis
Control of DNA Capture by Nanofluidic Transistors
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pnc-Si from PECVD
The group in the attached paper have found a way to form pnc-Si using PECVD. They use a 300-15-300 nm OSO stack with a 850 C (50 C/s, 30 s) RTP to form ~13 nm pores. SiMPore attempted this in the past, but was not able to form pores. Using PECVD would be faster than our…
MgF2 Cytocompatibility #4
Summary: I have some ok images (20x) of cells growing on MgF2. My controls still look poor. Something about the stain is causing the TCP + NPN controls to detach ahead of the MgF2 material, even if they aren’t fully dead yet. I used acetone fixation, which worked well for the materials on the nanomembrane, but…
Biomed Microdevices (Griep et al, 2012) Summary
BBB On Chip (Griep et al 2012) Jascha sent me an article about a BBB device. Their device follows a very similar structure to that of the Booth and Kim paper, but closer to the optimized design that I created, using very thin, wide channels to generate a lot of shear stress (100 micron high,…
PETL’s SEM pictures
ByFernandoJust wanted to show the detail of PETL channels. A couple of interesting things: The adhesive layer(s) are pretty thick, and look pretty smooth after heat curation. Also, the channels are slightly beveled, probably due to craft cutter blade.
Discoloration – autoclave and Sepcon
I did an experiment earlier this week in the Sepcon and flat format. I intentionally broke membrane windows so that I could compare chips with no intact membranes vs. chips with 1 intact membrane (and also the effect of autoclaving). Unfortunately, all of the flat chips discolored overnight, so I couldn’t see any differences between…
Cell Spreading on pncSi and glass
Spreading of cells (huvec and fibroblasts) on pncSi and glass was observed at ~37 C in L15 media (+ 10% FBS) for ~5 hours. Its observed that the cell spreading is pretty similar on both the substrates and the time lapse movies can be seen from the following links: huvec_glass_sprd huvec_membrane_sprd fibroblast_glass_sprd fibroblast_membrane_sprd Somehow its…