Solid State Nanopores in Biosensing

There is some non-uniformity in air permeability based on the position but it is not very clear for wafers 318 and 319. The full wafer measurement in future will make this dependence more obvious.Permeability of w319 is much higher then of w318 (RTP 1000C and 900C) as expected from TEM images where w319 has higher…

One of the features of the gold nanoparticle separations in SepCons that was under-appreciated by the reviewers at Science was the fact that we could get very high sieving coefficients in the neighborhood of the cut-off. For 5nm gold the sieving coefficient was 0.8 (i.e. the filtrate was 80%  as concentrated as the stock solution)…

While wafers 670 and 673 did not hold up to diffusion experiments, they were strong enough to perform pressurized separations using the pressure cell.  Each experiment lasted for 40min, although the average flow was only about 5ul for this duration. 673 has a pore cutoff around 30nm (refer to Dave’s post).  The following gel shows…

I attended the 2014 Gordon Research Conference (GRC) on Fuel Cells in August. For those of you not familiar with Gordon conferences, I will make a plug for them as a great venue for learning much detail and interacting closely with many of the major contributors in a specific field. GRC has a wide variety…

As I mentioned in the meeting this morning the SC267 samples have run out so I have begun testing SC269 for use in my experiments. This post pertains to a BSA diffusion experiment that I set up yesterday and allowed to run overnight. I took two SC269 samples; “treated” the first for 20min at 150C…

During the past few weeks, I have been experimenting with different array setups for diffusion. I have been working with BSA, but I will move to APOBEC3G protein once the arrays Barrett designed are finished. All of the pnc-Si arrays used were treated with UV-ozone. Treating with UV-ozone cleans the surface and helps prevents the…