These are cross sections of my comsol diffusion model. Each chip has 6 square wells terminated in a membrane. This cross section cuts across the two middle wells. Concentration contours are in 0.025 intervals.
6 hours:
12 hours:
18 hours:
24 hours:
These are a couple of figures that may appear in the supplementary materials for the permeability paper. The first tries to explain that most of our permeability is due to the largest pores. The lines plotted are the cumulative number of pores at each size (blue) and the cumulative permeability (green). The lines show that…
In our prior work we showed that endothelial cells form far fewer focal adhesions on microporous SiO2 membranes compared to non-porous SiO2 and tissue culture plastic (see prior post by Ana). We performed this analysis at 24 hours, which seems to be the standard in the literature. Interestingly, we found that the number of FAs…
In an effort to understand the material property using burst pressure, a few key variables have to be analyzed to determine their effect on burst pressure. These variables are: 1) Shape : a) Maximum Dimension of the slot. b) Minimum Dimension of the slot. 2) Active Area. 3) Effective circumference. 4) Number of features on…
Introduction Previous experiments completed by Hayley Miller investigated the effect of small extracellular vesicles (EVs) collected from Adipose Derived Stem Cells (ADSCs) on wound closure velocity and cell speed. Her previous related post can be found here. It was initially hypothesized that EVs play an important role in wound healing and affect the wound closure…
See my previous post for background information. It has been established that diffusion of small particles (diameter < roughly 1/3 pore diameter) across ultrathin membranes is mediated almost entirely by the ability of the particle to discover a pore, rather than by its ability to diffuse through a pore once one has been found. In…
This is in continuation to the studies that I published here. I used two types of membrane surfaces: nano nitride trenches (the back side of membranes) with pure nitride on the surface, and zero-second-etch nano nitride with a completely intact pncSi cap on the top. These two surfaces basically act as materials with two extreme…