SONY backing organ-on-a-chip development

Tom came up with this idea of using these membrane with precise thickness and pore size control to obtain a critical thickness and pore size, beyond which neutrophils cannot go transmigrate. N-Formylmethionyl-leucyl-phenylalanine (fMLP) was used in the lower channel to serve as a chemotactic factor for transmigration. Additionally, for membranes with pore sizes or thicknesses…

Hi All, Presented in this post is the following paper, titled: “Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices” [REVIEW] exosome handling in micro and nano devices Keynote presentation: [PRSENTATION] NRG (2015-11-16) exosomes

One question we recently had was what does it look like when we perform a separation experiment when a membrane has a pinhole. I selected two membranes off 621 that appeared to have pinholes on both slits. I applied 1:2 standards to the top and allowed to diffuse for 24 hours. I collected the retentate…

I’ve now made 18 pores in monolith devices, with only 1 real success, which was the first one that I report on already. All of the rest have failed for various reasons, mainly relating to the silicon nitride membrane in which the sensing pore is fabricated. The first issue is fabrication time. Fabricating a pore…

I will keep this post short and start by saying that the process of establishing a reliable set-up for nanosphere deposition, by evaluating the repeatability of the deposition parameters, has been longer than anticipated. The nanospheres self-assemble at the hexane-water interface and stabilize laterally through electrostatic forces. The main deposition steps are: Add water to…

Just in case you missed this one: www.nature.com.ezp.lib.rochester.edu/nnano/journal/v2/n11/full/nnano.2007.354.html This article makes the the previous papers seem mundane. It has inspired me though – maybe we can create a computer simulation that will demonstrate that pnc-Si membranes will dance and sing songs under the correct conditions. I will leave the choice of genre to the programmer…