Silicon Ideal to Culture Patient-On-a-Chip | Insight & Intelligence™ | GEN

After some experimentation with acetylene concentration and anneal temperature, I was able to find a carbonization recipe that appears to shrink our pores by 1/3 the original diameter.  Below are images of an untreated sample (TEM 148: 15 nm pnc-Si 1000 RTP) and a carbonized sample (see recipe at end of post). A closer look…

Permeability was calculated with Dagan theory for membranes in this post.  Pore processing was performed and r.mat files were run through the programs used to calculated permeability in submitted Science paper. No Carbonization Experimental: 591 ul/(min*PSI*cm^2) Theoretical: 801 ul/(min*PSI*cm^2) Carbonized (6.2 nm taken out of diameters) Experimental: 289 ul/(min*PSI*cm^2) Theoretical: 438 ul/(min*PSI*cm^2) It seems that there…

As you may already know, we are writing a review article for the Electrophoresis journal on nanofabrication methods. This post is to request your feedback on the figures included in the manuscript. The main objective of figure 1 is to compare top-down and bottom-up processes to justify the use of the methods reviewed in the…

ALine Capture Device In this post I will go over some of my recent work that is a continuation of Kilean’s research concerning extracellular vesicle (EV) capture and characterization. In the past, this was done using a tangential flow filtration (Figure 1) scheme and clamped devices featuring nanoporous membranes (Figure 2). These devices are straightforward…

Hi all, the technique of UV Ozone bonding (of PDMS to glass, Si or pnc-Si) is now complete, serendipitously. Hsin from Miller lab want to bond PDMS to glass, they tried plasma oxidation treatment and it worked.  The method is as followed: plasma oxidation treatment for 35 sec (which did not bond the sample, when…

This morning I did a little work with the track etched membranes (0.05um 13mm). I talked with Paul over in Hopeman and he is currently working on making a small coring tool to cut out the membranes (it should be done by the end of the day). In the mean time I figured out that…