Modeling pericyte loss in CNS disease using the µSiM platform to understand post-operative delirium superimposed on dementia – Michelle’s MPS Talk
MPS 2024
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Using Dual-Scale Membranes as a Model for a ‘Leaky’ BBB
Introduction Many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are associated with an early breakdown of the blood brain barrier (BBB). This includes an increase in permeability and pericyte degradation [1]. We hypothesize that using dual-scale (nanoporous and microporous) membranes in the µSiM-BBB model will create an inherently ‘leaky’ BBB which can be used…
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Little Back Dots in Coated Controls … How We Wonder What You Are.
Introduction We are investigating some issues seen with long term attachment (up to 6 days) of the EECM-BMEC-like cells seen by collaborators in Bern, where they noticed black aggregates on the coated control devices that get worse at day 6. Some attachment issues and aggregates have also been seen at the University of Rochester in…