In determining an appropriate animal model for hemodialysis efficacy, several metrics need to be compared to the human vasculature. Blood volume, blood pressure, and heart rate could effect the suitability of these animals to model clinical hemodialysis. Blood volume can be estimated as follows. Blood weight is ~ 7% of body weight, the density of…
We’ve been using gold nanoparticles (available for ~$60 for a 20mL bottle from BBI in sizes of 2, 5, 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 200, and 250 nm; for ~$80 for a 25mL bottle from Sigma Aldrich in sizes up to 400 nm) for years in the lab. This post highlights some of…
For the upcoming tests I have planned for H2 purification, I need a fixture to hold the pnc-Si membranes (Sepcon format) that is compatible with operation up to 500 C. No polymers are going to work. I describe the approach I’m working on below. I heard that Karl is developing a holder similar to what…
During the recent visit of Greg Madeijski to our Institute of Biophysics, Imaging & Optical Science (IBIOS) here in Nottingham we had the opportunity to try imaging cultures of cells on several nanoporous membranes, including CytoVu’s and also the unsupported TEM grids without SiN. Here is a short summary of our adventures, along with some…
I have been talking with JP about getting some pnc-Si membranes coated with ~10-20 nm layers of Pd (or Pd-Ag) to do preliminary tests on hydrogen permeation devices. Tom and I are thinking of submitting a proposal. This kind of technology has been used industrially and follows the general principle shown below: These operate at…
Instantaneous Clearance: Kd CBi, and CBo are the concentration of solute in the blood at the input and output of the dialyser. CDi and CDo are the concentration of solute in the dialysate at the input and output. QBi, QBo, QDi, and QDo are the flow rates at the inputs and outputs. The volume of…