Endothelial Vacuolization Induced By Highly-permeable Silicon Membranes

Here is an aggregate of the recent posts/data on the Hemodialysis Project … Device Design/Demo Design idea for assembling multiple chips Gasket design for counter flow dialysis chip Peclet chip demo – > Dialysis Membrane modifications to prevent protein binding (HD PEG) Protein binding is reduced by both Adarza and Shestopolov treatments Damage of pnc-Si by…

Silicon nanomembranes are ultrathin, free-standing structures that vary from 10 – 100 nm in thickness. These membranes are at least 1 order of magnitude thinner than the thinnest polymeric membranes. Pores can be manufactured on these membranes to have diameters ranging from 5 nm – 10 μm with porosities ranging from 2 – 20%, allowing…

This is a recent paper in Nature Materials that shows stem cells are influenced by prior culture on varying stiffness substrates. This means that when cells are induced towards adipogenic or osteogenic lineages, their prior culture history on a stiff or soft substrate affects their future differentiation. This is further evidence that in vitro culture of stem…

Many thanks to JK, Dean and Gunner (Webster HS) for compiling this table. Take homes … NPN-O has smaller pore sizes, lower porosity than NPN at the same thickness (50 nm). All materials have slightly asymmetric pores (~ R1/R2 = 0.75). Top-side and bottom side pore distributions are not the same. The original NPN material…

Lately, Anant and I have been doing our discoloration experiments under purposely harsh conditions so we don’t have to wait for multiple days for experiments to finish. We have lots of evidence that the 3D format slows down discoloration (post1, post2, post3). This experiment was to test how long samples will last in 3D format…

Over the summer, I have been working on a project with Rick Waugh that focuses on separating white blood cells from red blood cells. The goal is to be able to take a lancet droplet of whole blood and perform an analysis on this blood, whether it be for white blood cell phenotyping or exosome…