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EO as a function of pore radius
From Jess’ manuscript … From Wikipedia … From Tom’s ACS nano paper … The Dagan equation (2) for flow through short pores used to predict flow through pnc-Si is given by: where r is the average pore radius, DP is the pressure drop across the membrane, l is the membrane thickness and m is the…
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Impact of membrane thickness on EO
One of the surprising results of Jiracai’s studies with thick and thin membranes was that the thicker membranes had a lower capacity to support back pressure than the thinner membranes he used (see table in this post). This is counter to our original expectation; Since we know that much thicker EO membranes can support 50…
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Efficiency of EO
Jirchai summarized his data in this table … A question raised by a reviewer of our PNAS submission – and one that we’ve had for a long time – is what is the efficiency of the pump. The electrical power provided is calculated in the table for each configuration. As Chris mentioned in group meeting,…
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EO Pressure/Flow Relationship
When we submitted the EO paper way back one of the reviewers made the following comment … What is the “head pressure” P_max, i.e. the maximum back pressure that would stop the pump? For any linear electrokinetic phenomenon such as EO pumping, the flow rate decreases linearly with backpressure until a certain point (“head pressure”)…
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Coulter Foundation Presentation
On Monday I presented our progress on the hemodialysis project for the Coulter Foundation. They seemed very pleased with our progress and impressed with our team. Its a tough crowd and for the first time, I sensed they had confidence in us. I’ve uploaded my presentation to the blog (PDF; ppt). Their primary points of…
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EO Update
On the 13th of September we reviewed our recent progress on EO. Maryna and Jirachai (Borkholder group) gave presentations. I’ve uploaded PDF files of each of their presentations. Maryna’s presentation: MarynaEO Jarachai’s presentation: EO_Testing_Report (PPT) EO_Testing_Report (PDF) Bubble formation in electrolytic cells
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Thermodynamic Efficiency of EO with pnc-Si
EO permeability: We often refer to the ‘efficiency’ of EO with pnc-Si as being very high, but this may not be the case. What is actually high, as in the case of the other modes of transport, is the ‘permeability’ in EO. Dimensionally, the quantity we’ve referred to (in various places) as the ‘efficiency, the…
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Status the 'Harold Smith' Project
This is my attempt to summarize where we are with our investigation into the use of membrane arrays in high throughput screening. The effort is known colloquially as the ‘Harold Smith Project’ because the model protein system comes from Harold and is inspired by work in his laboratory on HIV. The principle being tested is…
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A Different Look at Shigeru's Latest
The paper that came out from Shigeru’s laboratory earlier this year in Analyitical Chemistry (Ishimatsu et al. 2010 downloadable here) demonstrated that the permeability of pnc-Si membranes to small monovalent ions in 0.1 M salt is predictable from membrane geometry alone. The paper also shows that multivalent and/or large ions do not follow theory as…