Thanks to our collaborators at the University of Chicago we have now used NPN to demonstrate sodium/hydrogen exchange functions at the level of single EVs. This is first-of-a-kind evidence of protein function in individual EVs. It will be officially published in Communcations Biology and will soon be located at this DOI. What follows are key…
Introduction Inflammatory diseases have the potential to disrupt blood vessel permeability. This has serious ramifications for the blood-brain barrier (BBB), which is the interface between the vasculature and the brain. A healthy BBB allows essential nutrients to pass through while excluding molecules that might alter brain chemistry. If inflammation were to increase the BBB’s permeability…
First, last week I had some images taken with new “visiting” AFM. These were frontside of the membrane with parylene deposited from the well side and the front side with deposited parylene on it. 1-1. Parylene deposition was not successful and although the dummy wafer showed thickness of parylene about 22nm, I suspect the were…
Here is a PDF of the presentation I plan to give at BMES this year. The presentation is first an overview of our SiO2 membranes for cell barrier and co-culture models and then a brief summary of our cell-substrate and cell-cell interactions on porous and soft substrates. I am currently working on getting it under…
Submitted on March 14, 2014 Submitted Manuscript (PDF) Check Status
Goal: Is to produce a membrane has pockets to capture the extracellular vesicles EV’s. Membrane structure: Figure 1 shows the membrane structure. The membrane will have two pores sides: upper and lower. The pores on top are bigger than the bottom and the diameter of the pores should be similar to or larger than the…
