Silicon Ideal to Culture Patient-On-a-Chip | Insight & Intelligence™ | GEN
http://www.genengnews.com/insight-and-intelligence/silicon-ideal-to-culture-patient-on-a-chip/77900627/ Organs-on-Chips Remotely Monitored, Controlled via Google Glass
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Nair, R. R., et al. (2012). “Unimpeded permeation of water through helium-leak-tight graphene-based membranes.” Science 335(6067): 442-444.
Nair(Geim)Science12 Supplement Laminates of GO from 0.1 to 10 um thick on copper foil with an etched hole of 1 cm. Casually mentions >1.5 psi applied to materials < 1 um thick over 1 cm diameter hole. This seems to suggests a strong burst pressure but with no real data or experimental details, this is…
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Imidazole functionalized graphene oxide/PEBAX mixed matrix membranes for efficient CO2 capture
SEPPUR-D-16-00198 Abstract Mixed matrix membranes (MMMs) were composed of imidazole functionalized graphene oxide (ImGO), a CO2-philic nano-sheet inorganic material, and poly(ether-b-amide) (PEBAX) for CO2 capture. MMM doped with 0.8 wt.% ImGO exhibits the best CO2 separation performance, which shows the CO2/N2 selectivity up to 105.5 combined with CO2 permeability of 76.2 Barrer (1 Barrer=10-10∙cm3(STP)∙cm-1∙cm-2∙s-1∙cmHg-1), surpassing…
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CVB Conference in Paris (July ’15)
Program C. Gu – Harvard Seminal Experiments Reese and Karnolvsky 1967 Brightman and Reese (1969) Two unique features of CNS endothelium: Specialized tight junctions – Very low rate transcytosis. Tight Junction by EM Ben-Zvi et al 2014 Nature. Transcytosis becomes upregulated not tight junctions. 2-3x injection HRP injection. Tracer containing vessels travel in endothelial cells…
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Review: Ultrathin Silica Membranes with Highly Ordered and Perpendicular Nanochannels for Precise and Fast Molecular Separation
Xingyu et al; Supplement The authors of this submission to ACS Nano apply techniques for the creation of mesoporous silica thin films with vertically aligned nanochannels to create ultrathin (< 100 nm) silica membranes with ~ 2 nm nanochannels. The technique involves the growth of silica around surfactant templates followed by the removal of the…
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NSF STTR Goals
Phase II submission August 1, 2016 or January 30, 2017 UR Tasks – Biocompatibility by Feb. 1 2016 Channel design optimization by November 2015
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Sepsis Retreat
9:10 – 9:55am Tony Pietropaoli Must drink liters of water but not urinating. Retaining. Massive edema. Cases that recover must absorb 1/3 to 1/2 of all patient deaths in hospital are related to sepsis. May be an underlying cause but sepsis triggers the hospitalization and causes the death. – Liu JAMA 2014…
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Heart on a Chip (Healy Group)
Kevin Healy is a Phase I and Phase II awardee of the NIH Tissue Chip initiative. The goal of this initiative is to create ‘mini-organs’ ‘organs-on-a-chip’ ’tissue chips’ or ‘microphysiological systems’ (MPS) for higher throughput and more reliable drug discovery. The effort is also motivated by the failure of recent animal models to predict drug…
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Simple Sieving Results
I used the following parameters in the Simple Sieving Model (pardon the MATLAB syntax) Am = 1; %cross sectional area in cm^2 Do = 1*10^-7;% diffusion coefficient in the membrane in cm^2/sec P = .15;% membrane porosity; t = linspace(0,420,500); %time vector sec Qo = 1*0.00166; %militers per second (0.00166 = 10 ul/min) L =…
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Simple Sieving Model
In an effort to better understand and check Karl’s model of sieving, I’ve built a significantly simpler version. The goal is to investigate the potential benefits of thinner membranes in dead-end filtration and separations. In my model 1 ml of water is displaced from the top bucket to an originally empty bottom bucket with a…