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Heart on a Chip (Healy Group)
ByJimKevin Healy is a Phase I and Phase II awardee of the NIH Tissue Chip initiative. The goal of this initiative is to create ‘mini-organs’ ‘organs-on-a-chip’ ’tissue chips’ or ‘microphysiological systems’ (MPS) for higher throughput and more reliable drug discovery. The effort is also motivated by the failure of recent animal models to predict drug…
TEOS film stress
Kelly & I deposited 100 & 300 nm thick SiO2 films on bare wafers with the P5000 PE-CVD tool at RIT last week. The wafers were then annealed according to JP’s recipe overnight to stabilize the TEOS layer film stress. The stress was measured using the Tencor P2 profilometer by scanning across it before depositing…
Streaming potential -> Zeta potential
In this post I will describe recent streaming potential measurements for PES membranes and the calculated apparent zeta potentials from these measurements. Setup: 1. Fabricate Ag/AgCl electrodes: Silver wire at the anode in 1M KCl at 1mA current for 20 minutes. 2. Assemble streaming potential device: Electrodes are inserted into silicone chord o-rings and chamber…
Reversible nano-confinement with a post-filter
My last experiment did not go as planned, but the results are very interesting nevertheless, and might provide another interesting application for these tw0-membrane systems that we had not yet considered. The start of the experiment went as planned: painted PDMS on the chip, used additional PDMS to glue the gasket to the PDMS layer,…
The New Concentration Polarization Model Turns Out To Be Difficult To Implement In Matlab
This is part three of a series of posts on constructing a mathematical model of the movement of gold through a porous membrane. In part one, I implemented William Deen’s mathematical model of the electrostatic and steric effects that contribute to whether a gold nanoparticle will translocate through a pore. The mathematica and matlab code…
AFM-newer material and high "magnification"
Earlier this week, Maryna and I did some AFM of her samples. She vapor-deposited parylene on the well-side of pnc-Si and was interested in whether/how well that polymer got through the pores. We got some really interesting-looking scans, but I’ll let her post those images. As controls, we looked at clean chips from the same…
