Josh and I are taking a closer look at how the samples burst and what different factors can affect the strength of the membrane. We are specifically looking at minimum dimension, area, and perimeter. A wafer was designed that contained different sized samples. One of the three factors were held constant while the other two…
This post is a brief update on the previous post of HUVEC migration on 0.5 μm porous substrates. Brief Recap We compared cell migration on nonporous (np), 0.5 μm low porosity, and 0.5 μm high porosity SiO2 membranes. Low and high porosity refer to a center-to-center distance of two or three pore diameters, respectively. For…
In preparation for the ICNMM conference next summer (and more immediately, the paper they’ve requested by January) I’ve started thinking about what our membranes can offer extracorporeal membrane oxygenation, or ECMO. This post will begin with some background information that I think is particularly important and progress into what work I’ve done so far on…
Maryna’s presentation
Coming to a basement near you by the end of 2008 (assuming no delays that is). Pretty exciting in my opinion.
Introduction Endothelial cell detachment under flow on porous substrates has been a concern in our sepsis research since I began my work in the lab, and some time before that as well. As we plan on moving to microfluidic models that incorporate larger pore substrates and physiological shear stresses for extended periods of time, it…