Tendon-on-Chip Platform for Modeling Inflammation and Fibrosis in Tendon Injury

In Episode 3 of this series, I have begun working towards improving my COMSOL modeling for particle capture. In addition to running simulations, I need to run experiments to try and correlate real world solutions with simulated results. One of the major focus points of my work has been trying to explain the shape of…

This is the first set of studies to assess the hemocompatibility of pncSi surfaces based on the paper by Fissell and Roy. It looks for the behavior of platelets in the plasma upon interaction with pncSi surfaces. Biological Motivation: Platelets are one of the most important components of the human immune system and also one…

The idea here is to use nano membranes that have been integrated in a chip with the intention to mix otherwise laminar flow streams.   It was suggested at one of the meetings that I should superimpose the streams, then have one of them come through the membrane into the other stream.  The idea is…

Cellulose Membranes I set up a 24 hour diffusion experiment with Millipore 30kD cellulose membranes as shown in this picture: After 24 hours I collected retentate and filtrate and visualized on the following gel: I didn’t expect to see a separation so similar to our pnc-Si results in this format considering the extremely poor dialysis…

Hopefully in the next week we will be submitting the following manuscript … X. Li, D. Johnson, W. Ma, H. Chung, J. Getpreecharsawas, J.L. McGrath, A.A. Shestopalov, Modification of Nanoporous Silicon Nitride with Stable and Functional Organic Monolayers, ACS Chemistry of Materials  (2016) submitted. Here are the highlights … Traditional silanization of silicon materials uses…