Slides for Jan 12th STTR Update

On Friday Josh and I assembled  Sepcon chips with calculated porosity of ~6.5 %, and avg. pore diameter of ~40 nm into Sepcons.   I was able to pass 40nm gold through the pores (we don’t have any gold larger than that).  Note the “Bad” retentate – for some reason one of the sepcons didn’t filter anything. On…

Just wanted to show the detail of PETL channels.  A couple of interesting things:  The adhesive layer(s) are pretty thick, and look pretty smooth after heat curation.  Also, the channels are slightly beveled, probably due to craft cutter blade.

Since the last post we have been working on obtaining replicates with wafer 101 chips.  The goal was to show salt dependent filtration changes.  These chips were different from the ones originally used in that the pores were much smaller (7-15nm diameter) and did not exhibit any merging.  It was suggested that we perform an…

I have uploaded the TEOS process outline: TEOS is tetra-ethyl-ortho-silicate, or equivalently tetra-ethoxy-silane. TEOS slowly hydrolyzes into silicon dioxide and ethanol when in contact with ambient moisture. IMPROVEMENTS: -This process prevents us from having to expose the front-side of the silicon during processing. Concurrently, this eliminates the need for aggressive cleaning of the front surface…

Introduction In previous posts by both Alec and Kayli, the urea clearance performance of our bench-top single-pass dialysis devices has been described. Results regarding devices containing untreated, PEG-treated, and nonporous membranes can be found in the “Current Dialysis Research [McGrath Lab, December 2017]”, https://trace-bmps.org/current-dialysis-research-mcgrath-lab-november-2017/ and “Updated Dialysis Research” posts. https://trace-bmps.org/updated-dialysis-research/ The nanomembranes present in these…

Introduction The invasion of Staphlyococcus aureus into the cracks of cortical bone leads to osteomyelitis, a devastating disease often resolved by amputation [1]. The μSiM platform has been used to study the genetic mechanisms of S. aureus invasion. The membrane pores mimic the network of cracks in bone, referred to as the osteocyte lacuno-canalicular network…