I’ve been trying to make the following device work for the past few years: The people who have been studying this have been trying to use the phenomena to mix solutions, or using arrays of mismatched electrodes to generate a sort of conveyor belt pumping mechanism: My idea is to use the electrokinetic phenomena of AC…
Abstract Endothelial cell attachment to porous substrates via focal adhesions is initially affected by pore spacing and not absolute porosity. Maturation of endothelial monolayers via cell-cell interactions occurred over the same time course regardless of substrate porosity, pore size and contact area. Cell-matrix interactions at maturity were dictated by substrate stiffness. Data [missing figure] Fig. 4 Endothelial…
We desire to test the electrical perfomance of our membranes in the iBidi chamber. For comparison, I am using a gold standard Ussing chamber format to examine the contribution of our membranes to the overall frequency response of a system. I am using both a matlab model and a web-simulator (www.circuitlab.com) to examine an equivalent circuit model…
I have been working on developing a microvessel mimetic using our silicon membranes. Just as a recap of vascular biology, the basic components of a microvessel are endothelial cells, the basement membrane secreted by them (presence of perciytes is a plus), and extracellular matrix (ECM) on the abluminal side. This ECM is predominantly composed of…
Paper: Oo2016 Supplementary Info:Oo2016SI Abstract: Design and fabrication of three-dimensionally structured, gold membranes containing hexagonally close-packed microcavities with nanopores in the base, are described. Our aim is to create a nanoporous structure with localized enhancement of the fluorescence or Raman scattering at, and in the nanopore when excited with light of approximately 600 nm, with a view…
I have just completed testing and documentation of a MATLAB GUI designed to allow anyone to make predictions of the clearance behavior of solutes though our membranes in tangential flow. I’m uploading the file here, which includes all the MATLAB code for the GUI, dependancies, and documentation. It will also appear under the resources tab on the…
“Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy” – Link “First Implantation of Silicon Nanopore Membrane Hemofilters” – Link My slideshow – Fissell Journal Club Slides These are two references for permeability and selectivity. Neither shows actual permeability or selectivity. Fissell(Roy)JMS10 Kahnani(Zydney)JMS09 Here is the chemical PEG modification paper…
http://www.genengnews.com/insight-and-intelligence/silicon-ideal-to-culture-patient-on-a-chip/77900627/ Organs-on-Chips Remotely Monitored, Controlled via Google Glass
Since I’m now back pretty much full time on the filter project, I’ll give a quick update about where we stand and where I’m going with it, as well as some (negative) results from this week. On the membrane transfer side of things, we finally have a tool that can produce fine enough vapor…
Porous metal-organic framework (MOF) crystal is obtained by precipitation after mixing an aqueous solution of cadmium nitrate and the solution of 4,4’-bipyridine in anhydrous ethanol. It is found that the crystallization occurred when ethanol evaporated from the mixture. As a result, 4,4-bipyridine became supersaturated and complexed with Cd forming an infinite two-dimensional sheet as shown…