Image analysis for force from videos of deflected PDMS beams In the summer, Yimei Du from University of Rochester visited Truskey lab to help with the μSiM Vasc-SkM system. Besides working with the chip culture, she helped improve the image analysis of the videos of PDMS beam deflection for more accurate myobundle force analysis. We…
A central goal of our research is to replicate the blood–brain barrier (BBB) within the µSiM platform. To establish this platform as a valid tool for transport neurotoxicity assays and drug development studies, it is essential to confirm that the barrier not only forms tight junctions but also exhibits functional efflux transporter activity. The BBB…
LoI and QS Slides for NIH monthly mtg 28 Aug 2025 Letters of Intent Draft sent to C-Path on August 15 CRS/ICANS JDM
Human gene/allele/trait: all caps, italicized. Human protein: all caps (no italics). Mouse gene: First letter caps, all italicized Mouse protein: First letter caps, not italicized.
Manufacturer’s Data Delivery Date: 8/25/2025 (picked up and logged by Ahmet Gurcan) Membrane Type: 1 Micron MicroSlit SKU: MSSN400.C-3LX.1-1.0E2 Lot Number: 240701-05 Quantity Received: 250 Manufacturer Test Report: Flow Data Avg in SLPM 1psi: 1.83 2psi: 3.47 4psi: 6.34 15psi: 15.6 Burst: 26.99 UR Testing Slit Width: Slit Length: 3 Membranes from this lot were…
Status of the Quality System Team – June 27, 2025 Quality System Update – 27 June 2025
Work in progress … **************** T cell–Engaging Immunotherapies Pose a Predictable but Complex RiskT cell–engaging bispecific antibodies (BsAbs), particularly those targeting CD3 and a tumor-associated antigen, have emerged as a powerful class of immunotherapies. These agents leverage endogenous T cells to induce targeted tumor cell death, often achieving deep and durable responses in hematologic malignancies….
Since the last TraCe-bMPS update in April, we continued to explore different conditions to optimize the μSiM hVasc-SkM systems to obtain stable results. Enhanced imaging for PDMS beams with Rhodamine staining Previously we established a MATLAB program that detects the border of the PDMS beams and converts the movement of the PDMS beam from myobundle…
Manufacturer’s Data Delivery Date: 3/26/2025 (picked up and logged by Ahmet Gurcan) Membrane Type: NPN 2 Slot Wide Short SKU: NPSN100.C-2LZ.4 Lot Number: 240919-13 Quantity Received: 150 Manufacturer Test Report: Pore Size: 63.2 nm Porosity: 22.9% Flow Data Avg in SLPM 2psi: 0.314 4psi: 0.594 Burst: 6.899 PSI UR Testing Porosity: 12.09% Pore size: 55.25…
Manufacturer’s Data Delivery Date: 4/14/2024 (picked up and logged by Ahmet Gurcan) Membrane Type: NPN 1 Slot SKU: NPSN100.C-1LZ.0 Lot Number: 240803-20 Quantity Received: 220 Manufacturer Test Report: Pore Size: 51 nm Porosity: 12% Flow Data Avg in SLPM 2psi: 0.124 4psi: 0.249 Burst: 5.628 PSI UR Testing Porosity: 10.1% Pore size: 51.81 +/- 13.49…