Journal Club for June 26
Very last minute but here goes … Voting closes at 7 pm tonight. Vote for 2! [yop_poll id=”4″]
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Effect of increasing dialysate flow rate on diffusive mass transfer of urea, phosphate and β2-microglobulin during clinical haemodialysis
Bhimani(Ward)10NDT This is a useful paper for our work on Hemodialysis. The authors examine the clearance rates of urea, B2 microglobulin and phosphate as a function of dialysate flow rate . Two things surprise me in this paper: 1) the clearance levels achieved are much higher than I’ve come to expect, and 2) the clearance…
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Silicon Oxide Liftoff Update
I have been exploring the efficacy of different methods for removing the native oxide from the surface of the sacrificial silicon layer prior to liftoff etch with XeF2. As a reminder, with liftoff of SiN membranes, one can simply dip the sample in BOE solution for a few seconds to strip the native oxide. This…
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Fisher Team Update: Week 3
MAKING CHIPS We now have our own SU-8 mold (with the help of Brian & Alex at URnano) and have started producing chips (see below) with our channel designs. Together with the chips produced last week, we have accomplish one of our objectives: To build a collection of chips for classroom use. With the acquisition…
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(Journal Club) Measuring the Zetapotential and Protein Translocation Behavior of Single-pore SiN
This paper (SiN paper) by Ulrich Rant et. Al. details several experiments conducted with a single pore drilled through a SiN membrane via TEM. They measure the relationship of pH vs. zetapotential for both a model protein (avidin) and their membrane, and then see how protein moves across the membrane at different pH’s. Translocation is…
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On the Efficiency of Center-Based Dialysis
The typical dialysis center experience targets a urea clearance value of KT/V = 1.4 (KT/V is explained by Dean here). We can use this knowledge to solve for the clearance rate of a typical dialysis center experience. Assuming 40 L of blood (body weight is about 60% water so this corresponds to 145 lbs,) 4…
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What is a glomerulus and where is it? How many are there?
The Bowman’s Capsule contains the Glomerulus, these are both part of a nephron of which the kidney has a gazillion. (The real estimate is the each kidney contains a million nephrons) Here are some pics to orient you. These give some idea why the Fissel group uses slits. The glomeruli are the main filtration device…
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ASAIO Conference
Final-Program-MMD-2014.prog_ June 19 Random Notes • Blood Stasis is the main cause of thrombosis • 23 French can access the venous system • 3 French per mm • Extracorporal Membrane Oxygenator used in the treatment of Cardiogenic Shock ◦ Use ECMO as a short term mechanical assist device ◦ Peripheral vs. Central venus access –…
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Paper-Based Microfluidics
Glavan et al 2013 Lab on a Chip This paper from the Whitesides group details an interesting way to fabricate paper-based microfluidics. They treat ordinary paper with a fluorinated silanization process to render it hydrophobic, and use a Silhouette cutter to scratch a channel into the paper. When covered with double-sided scotch tape, conduits are…
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Differential Cell Adhesion on Mesoporous Silicon Substrates
This paper was found when looking for details on quantifying cell spreading and adhesion. The paper discusses how the group has made mesoporous silicon wafers and their success with growing human umbilical vein endothelial cells on the wafers without additional proteins. DifferentialCellAdhesion