I’ve been trying for a year now to make a nanofluidic transistor – a nanomembrane with a thin layer of metal coated in dielectric that allows for the dynamic modulation of the sieving characteristics of the chip. Beginning with the last 14 chips from wafer #1081, I coated them in ~3 nm of Ti and…
All separations are 30 nm (diameter) gold nanoparticles in a 56 nm pore setup, with other parameters as described in my last post. Y-axis scale bar is in meters, x-axis scale is meaningless (the simulation is 1-D, and the width is added just for clarity’s sake). The membrane is at y = 0. Color corresponds…
I have wondered if it were possible to create free-standing, nanoporous nanomembranes out of other materials (rather than my MgF2 process). The process is general enough that it should work. The major factors are Etch Selectivity between the substrate and the deposited material Film Mechanics (some films tear themselves apart due to the relative sizes…
These curves were all generated using the following package of matlab functions and scripts: (Sieving copy – run Find_Sieving_Coefficient_boltzmann.m – it’s set up to generate concentration profiles right now). The program begins with a ‘standard separation’ that uses the following characteristics: Pore diameter: 58 nm Particle diameter: increases from 20 nm to 56 nm in 2 nm increments…
After a great deal of debugging and thought, I’ve made a small breakthrough in the modeling of sieving behavior using MATLAB, Bill Deen’s electrostatic model of pore-particle interactions, and a boltzman distribution to model concentration polarization (previous blog posts: Part 1 Part 2 Part 3). I had made a small conceptual error while generating the algorithm…
We wanted to prove our previous findings that ADSC crawl toward HUVEC networks and alter them. We did this by using time lapse imagery to demonstrate the migration. We also wanted to show the process of HUVEC network formation. We wanted to use the time lapse imagery to see how quickly ADSC migrate to HUVEC…
Sometime in September, the group received the following invitation to write a book chapter: We, John Rogers from the University of Illinois at Urbana-Champaign and Jong-Hyun Ahn from Yonsei University, are editing a book that will be published by Wiley-VCH in 2015 on “Silicon Nanomembranes: Fundamental Science and Applications”. We would like to kindly invite…
Hi All, just a quick post to up date you on what we are up to. 3 Things going on in the lab: Ryan continues to make his nano particles using chips, he is loading them with an anti-inflammatory agent (parthenolide) and testing them on macrophages in vitro. Hopefully more on that soon. Niecy just…
Hi all, Presented here is a prototype of an “all purpose” SiN chip system for use in cell studies. The reason it was called “all purpose” because it is intended for simple cell culture and migration/chemotaxis studies. This prototype is essentially a less complicated and cheaper version of the device that was showcased in our…
I went to Kidney Week in Philly, Nov 13-15. American Society of Nephrology. I spent most of my time in the Bioengineering talks and posters. Here are some highlights. I put the Abstracts pdf on the cloud. Recellularization of Vascular and Tubular Compartments of Rat Kidney Scaffolds with Embryonic Stem Cells Basically, they perfused…