A few weeks ago, Josh and JP brought me some 3 window microslit membranes that had edge aligned 8 and 9 μm slits. While these may seem to be quite large for most applications, they are in fact perfect for working with whole blood. The experiments that we have planned for these membranes are based on the…
This post summarizes a quick update on 2 different goals: 1) membrane releasing and 2) SU-8 strain reduction. Here you will find basic background on some of the work that has already been conducted and the planned experimental work that will be conducted in conjunction with Bob Carter and Cody Soule (Co-op student). 1. ZnO as…
Intro: Hi all, as we investigate the formation of HUVEC focal adhesions on porous SiO2 membrane , we also looked at fibronectin fibriollogenesis. Interestingly, it appears that after 24 hr (since the initial seeding), the fibronectin fibrils formed by HUVEC vary depending on the pore characteristics of the SiO2 membrane. In this case, we looked at…
We’re submitting the following paper to Separations and Purifications within the next two weeks: model-paper model supplement Below are the (almost) final versions of the figures from the paper. Figure 1: Schematic of Particle Distribution for Particles Rejected by Membranes The distribution is a quasi-equilibrium between convection towards the membrane and back diffusion, which is…
As the title states, this post is about shifting an arbitrary pore distribution in an NPN layer. Why would we want to do this? We believe that the underlying pore distribution and shape influences the properties of many of our devices (my SERS sensor work included). Jim has coined the term ‘bowl-with-a-hole’ to describe the…
Hello Everyone, So first of all, a quick reminder of what i have been working on: we were able to show the trapping of the beads by TE membranes, although in final step and after releasing of the beads, we could still see beads on the membrane, so we hypothesized that the beads are…
Photo Courtesy J. Adam Fenster, U of R We’ve had several of each of the two prototype reverse Sepcon designs professionally 3D printed for us (top photo). I did a few quick tests to see how they worked in the lab. “Fixed” Version This is designed to snap onto the outer lip of a 2…
As an introduction, my name is Alec Salminen. I received my BS in Biomedical Engineering at the University of Arkansas and am currently in my first year of the BME PhD program at the University of Rochester. As my rotation in the McGrath lab gets underway, I would like to share with the group my…
Dan Steiner Rotation Summary Abstract The purpose of this rotation project was to develop and test a clampable system for eventual use in scalable nanomembrane dialysis systems. The nanomembrane dialysis system will be miniaturized into a compact, wearable hemodialysis device that will provide more effective human dialysis treatment (Johnson et al. 2013). For initial tests, a…
Membrane pore spacing can modulate endothelial cell- substrate and cell-cell interactions (REVISION) We submitted our “focal adhesions” paper to ACS Biomaterials Science and Engineering late last year. We received reasonable reviewer requests from three reviewers. I think I am mostly finished with revising the figures. Here are the updated figures and my comments on what changed….